The Big Bang Theory is often compared to Genesis because both narratives are about the creation of the world. In the Big Bang, matter coalesced instantaneously. In Genesis, God spoke creations into being, which, at a peshat level, is most easily understood to mean that the creatures formed instantaneously at God's will. According to modern scientific analysis, modern humans are 200,000 years old. This is much younger than almost any modern species or natural phenomenon. Humans were created last in the order of creation in the Genesis story. Similarities and differences like these, raise theological questions about how science and the Biblical relate.

When Adam was created he is told he may rule the beasts and the earth yet he is also told he must serve and develop the land. Adam is told that he is being trusted with the land on the condition that he rules in a manner to preserve nature and mankind rather than abuse it selfishly for his own ends. The subservient nature of rulership is a fundamental principle of the United States. The President of the United States is generally considered to be the leader of the United States government; however to accept this position he must commit to “...preserve, protect and defend the Constitution of the United States.” (U.S. Constitution). Just like Adam, a new President is allowed to rule only if they also promise to aid and protect.

Rattlesnakes ensure that it isn’t just Eve who gets tricked by a snake. According to a National Geographic article from 2021, Rattlesnakes often use their rattles to make people think they are a lot closer than they are. Rattlesnakes do this to trick people into running when in fact there is no danger. Humans are potentially dangerous to rattlesnakes, so they attempt to scare humans away. Rattlesnakes do this to bison and hawks in addition to humans. This works because many animals and humans are instinctively afraid of snakes.

The U.S. says in 18 U.S.C. § 1111 that based on the circumstances killing someone can mean many different crimes were committed. If someone planned the murder, they are guilty of first-degree murder. If someone does not intend to kill someone but their actions caused their death, or the murder was a decision at the moment of the killing, then one is guilty of second-degree murder. The ambiguity in the Cain and Abel story would be hard on a jury. According to most commentators, Cain invited Abel to the field to kill him in secret. However, according to Daat Zekeinim, Cain and Abel had an argument that caused Cain to become so angry that he decided to kill him in the moment. This issue could make the difference in whether Cain is guilty of murder in the first or second degree.

In 2007, Nebraska State Senator Ernie Chambers sued God on account of natural disasters. Chambers said that God owed the world for all the damage he caused in the bible. Chambers also argued that God was responsible for all acts committed in God's name. Chambers said that God is responsible for protecting everyone and that God is responsible for every death he causes. The case was dismissed on a technicality, so no one has a definitive answer on whether God is legally responsible for any natural disasters.